Target Safety Assessment in 1 day
Ensuring the path to a safe cure for
cancer
is never lost in discovery
AutoTSA reads thousands of scientific papers, extracts the safety evidence that matters, and delivers a complete target safety assessment — fully automated, verifiably trustworthy.
Automation
From 1000+ papers to safety assessment. One click.
Point AutoTSA at a target and let it work. The entire pipeline — from literature ingestion to risk-ranked report — runs autonomously so you can start with the first version of the end report.
Evidence extraction
Every claim traces back to its source
AutoTSA extracts safety-relevant quotes from scientific literature and maps each finding to its evidence base — so you can always verify what the AI found.
"IL-11 signaling through IL-11Rα promotes cardiac fibrosis and contributes to adverse ventricular remodeling following myocardial infarction in both murine models and human tissue samples."
Schafer et al., 2017 — Nature
Extracted quotes
Structured output
Safety claims organized by category
Extracted evidence is synthesized into actionable safety claims, organized by organ system and risk category — the same structure toxicologists expect in a TSA.
IL-11 promotes cardiac fibrosis through activation of cardiac fibroblasts and TGF-β signaling
Anti-IL-11 treatment reverses established cardiac fibrosis in murine pressure-overload models
Elevated IL-11 correlates with adverse cardiac remodeling post-myocardial infarction
Genetic ablation of IL-11 signaling protects against diet-induced steatohepatitis
IL-11 drives hepatocyte death through ERK-dependent non-canonical pathway
IL-11 modulates macrophage polarization toward a pro-inflammatory phenotype in tissue injury contexts
Therapeutic neutralization does not impair immune defense in infection models
IL-11 is critical for decidualization and implantation; inhibition may impair fertility
For whom
Built for teams who can't afford to miss a safety signal
AutoTSA is our response to how LLMs change discovery. Our current focus is maximally improving automated TSA quality and are looking for partners to collaborate on this goal.
Pharmaceutical companies
Large pipelines of targets requiring continuous safety assessment as new literature emerges.
Biotech startups
Need rigorous safety evidence fast — without building a large internal toxicology team.
Contract Research Organizations
Deliver faster, more consistent assessments while maintaining full regulatory traceability.
About
GenAI-native from day one
Longtail Discovery has 20+ years of expertise in target safety assessments for the pharmaceutical industry. Every part of AutoTSA is designed to leverage domain expertise to maximally use large language model capabilities.
Safe
Find adverse effects
Confidential
Your data stays yours
Human-in-the-loop
Experts stay in control
Choose your LLM
Or add your own
Get in touch
Request a demo
See AutoTSA in action on a target relevant to your pipeline.